International Journal of Innovative Research and Development

Abstract

Background: Ayurvedic books like Sushruta Samhita, Bhaisajyaratnavali & Charaka Samhita have mentioned the importance of Arimedadi Taila in the management of Dental Diseases. Lot of Research was done to study the efficacy of Arimedadi Taila by the Ayurvedic Researchers.

Aim: Aim of the present study is to evaluate the efficacy of Arimedadi Taila in the Dental Patients by a qualified team of Allopathy and Ayurvedic Researchers.

Materials & Methods: 50 Patients attending Dental O.P at ESI Diagnostic Center, Jeedimetla with Periodontal problems were selected. Patients were given Arimedadi Taila and explained how to use every day and advised to report to dental department after 10 days and later after 21 days to evaluate the efficacy of the Arimedadi Taila in relieving of their symptoms.

Statistical Analysis Used: Chi Square Test

Conclusion: Arimedadi Taila was proved to be effective in reducing periodontal problems like bad breath, bleeding gums and swollen gums along with sensitivity of teeth in more than 80% of patients.

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Abstract

Dental and Bone graft   substitutes are used in Dental surgery, orthopaedic surgery and Neuro - surgery. . They are used in filling defects or voids resulting from bone loss due to trauma or deformity. Since decades autograft, allograft and mineral bone graft like Calcium phosphate, Calcium sulphate, Tri Calcium phosphate are being used. A novel bone biomaterial which is a nanocomposite of ECM and HA has been developed. ECM provides the body’s own natural bone growth factors to supplement the action of the bone graft.

We prepared   an ECM emulsion with a suitable organic solvent and blend it with simulated body fluid (SBF) for deposition of nano crystals is the first step. After initial evidence we optimized the SBF and ECM composition for faster nucleation and HA nano crystal growth. We are hypothesizing that the non-collagenous gap junction between tropocollagen in the collagen fibrils will be sufficient by optimizing collagen concentration to induce nucleation of HA and achieve high strength in short time.  To study the physical characterization of ECM-HA formulations (freeze dried sample) SEM and XRD were used.

The results showed that the materials mated successfully with evidence of HA

Deposition of ECM as demonstrated by Scanning Electron Microscope (SEM). The X ray diffraction shows proper crystal deposition.

This novel biomaterial which is an ECM-HA nanocomposite can address the downsides of autograft, allograft and existing synthetic bone substitutes. Such a novel bilateral composite will be a common substitute for multiple clinical needs     as it can create most of the device formats like cortical, cancellous, granules, paste etc.

It can be developed as a therapeutic range of class I predicate devices for various bone defects managements

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Cartilage tissue engineering is required for the repair of injured cartilage and osteoarticular diseases. Since cartilage cells at the site do not grow to form new cartilage cells, therefore, tissue engineered cartilage approaches aim at cultivating chondrocytes in vitro, and to reintroduce the engineered cultured cartilage tissue into the damaged region. In our study, human cartilage cells cultured on novel microcarrier made of ECM (Extracellular matrix) proteins exhibited hyaline cartilage differentiation, cell proliferation and biocompatibility. Engineered cartilage tissue will be a promising method for the treatment of Cartilage defects.

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